Inherited Anti-Thrombin Deficiency (Last Updated - 3/6/2005)

-pts. have only ~40%-60% of normal anti-thrombin levels (vs. 25% in Acquired Anti-Thrombin Deficiency)
-so may cause Heparin resistance --> but most pts. respond normally to IV Heparin dosing

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References:

Goodman & Gilman's: The Pharmacologic Basis Of Therapeutics - 10th Edition - 2001. Chapter 55.